{"id":68525,"date":"2025-05-27T23:37:01","date_gmt":"2025-05-27T14:37:01","guid":{"rendered":"https:\/\/hibulls.com\/?p=68525"},"modified":"2025-05-27T23:37:03","modified_gmt":"2025-05-27T14:37:03","slug":"05-28-%ed%88%ac%eb%bf%941-%ec%b6%94%ec%b2%9c%ec%a3%bc-%ec%98%ac%ed%95%b4-%ec%a3%bc%ec%9a%94-pipeline-%ec%9e%84%ec%83%81-%ea%b7%b8%eb%a6%ac%ea%b3%a0-%ea%b8%b0%ec%88%a0%ec%88%98%ec%b6%9c","status":"publish","type":"post","link":"https:\/\/hibulls.com\/?p=68525","title":{"rendered":"[05.28] \ud22c\ubfd4(1++) \ucd94\ucc9c\uc8fc : \uc62c\ud574 \uc8fc\uc694 Pipeline \uc784\uc0c1, \uadf8\ub9ac\uace0 \uae30\uc220\uc218\ucd9c \uae30\ub300 \ubaa8\uba58\ud140\uc774 \uc794\ub729"},"content":{"rendered":"\n

(\uc774\ubbf8\uc9c0 \ub0b4 \uae00\uc790\uac00 \uc798 \ubcf4\uc774\uc9c0 \uc54a\uc73c\uba74 \uc6f9\ube0c\ub77c\uc6b0\uc800, \ud734\ub300\ud3f0 \ud654\uba74\uc744 ‘\uac00\ub85c\ud654\uba74’\uc73c\ub85c \ubcf4\uc2dc\uac70\ub098, \uc774\ubbf8\uc9c0\ub97c \ud074\ub9ad\ud558\uba74 \ud655\ub300\ud574\uc11c \ubcf4\uc2e4 \uc218 \uc788\uc2b5\ub2c8\ub2e4.)<\/em><\/p>\n\n\n\n

\u2605\uc62c\ub9ad\uc2a4(226950)<\/p>\n\n\n\n

-\uc131\uaca9 : \uc2a4\uc719~\uc911\uae30
-\ucd94\ucc9c\uac00 : 51,700\uc6d0
-\ubaa9\ud45c\uac00 : 60,000\uc6d0
-\uc190\uc808\uac00 : 40,000\uc6d0<\/p>\n\n\n\n

-\uae30\uc5c5 \uac1c\uc694<\/p>\n\n\n\n

RNA \uac04\uc12d(RNA interference; RNAi) \uae30\uc220 \uc911\uc5d0\uc11c mRNA\ub97c \ud0c0\uac9f\ud55c \uc790\uac00\uc804\ub2ec \ube44\ub300\uce6d siRNA \uae30\uc220\uacfc GalNAc-asiRNA \ud50c\ub7ab\ud3fc \uae30\uc220\uc744 \uae30\ubc18\uc73c\ub85c \ub2e4\uc591\ud55c \uc2e0\uc57d\uc744 \uac1c\ubc1c \uc911\uc784. RNA \uac04\uc12d \uae30\uc220 \ud50c\ub7ab\ud3fc \ubc0f \uc2e0\uc57d \ud6c4\ubcf4\ubb3c\uc9c8 \uae30\uc220\uc744 \uad6d\ub0b4\u00b7\uc678 \uc81c\uc57d\uc0ac\uc5d0 \uae30\uc220\uc774\uc804\ud574 \uc218\uc775\ud654\ud568. \ud45c\uc801 \uc720\uc804\uc790\uc5d0 \ub530\ub77c antisense \uac00\ub2e5\uc758 \uc5fc\uae30\uc11c\uc5f4\uc744 \ubcc0\uacbd\ud558\ub294 \ubc29\uc2dd\uc73c\ub85c 3\uac1c\uc6d4 \ub0b4 \uc2e0\uc57d \ud6c4\ubcf4\ubb3c\uc9c8 \ub3c4\ucd9c\uc774 \uac00\ub2a5\ud55c \uae30\uc220\ub825 \ubcf4\uc720\ud568. RNA\uac04\uc12d \uce58\ub8cc\uc81c \uc2dc\uc7a5\uc740 2023\ub144 11\uc5b5$\uc5d0\uc11c 2033\ub144 42\uc5b5$\ub85c \uc131\uc7a5\uc774 \uc804\ub9dd\ub418\uba70, \uae00\ub85c\ubc8c \uc81c\uc57d\uc0ac\uc640\uc758 \uae30\uc220\uc774\uc804\u00b7\uacf5\ub3d9\uc5f0\uad6c\ub85c \ub300\uc751 \uc911\uc784.<\/p>\n\n\n\n

-\ud22c\uc790 \ud3ec\uc778\ud2b8<\/p>\n\n\n\n

\u25a0\ud53c\ubd80 \uad00\ub828 \uce58\ub8cc\uc81c Pipeline
\u2192\ube44\ub300\ud749\ud130 \uce58\ub8cc\uc81c OLX101A : \ubbf8\uad6d \uc784\uc0c1 2\uc0c1\uc744 \uc644\ub8cc\ud558\uace0, 2024\ub144 4\uc6d4 \ud574\ub2f9 2a\uc0c1\uc5d0 \ub300\ud55c \uc784\uc0c1\uc2dc\ud5d8 \uacb0\uacfc\ubcf4\uace0\uc11c(Clinical Study Report, CSR)\ub97c \uc218\ub839, 1\ucc28 \ud3c9\uac00\uc9c0\ud45c\uc5d0\uc11c \ud1b5\uacc4\uc801 \uc720\uc758\uc131\uc744 \ucda9\uc871\ud55c \uc0c1\ud669
\u2192\ub0a8\uc131\ud615 \ud0c8\ubaa8\uce58\ub8cc\uc81c OLX104C : \ud638\uc8fc\uc5d0\uc11c \ud0c8\ubaa8\ud658\uc790 25\uba85(4\ucf54\ud638\ud2b8, \ucf54\ud638\ud2b8\ub2f9 6\uba85, \ub2e8\ud68c\ud22c\uc5ec)\uc744 \ub300\uc0c1\uc73c\ub85c \uc784\uc0c1 1\uc0c1 \ud22c\uc57d\uacfc 8\uc8fc\uac04\uc758 \ucd94\uc801 \uad00\ucc30 \uc644\ub8cc, 2025\ub144 1\uc6d4\uc5d0 1\ucc28 \ud3c9\uac00\uc9c0\ud45c\ub97c \ucda9\uc871\ud574 \uc548\uc804\uc131\uacfc \ub0b4\uc57d\uc131\uc744 \ud655\uc778\ud55c \uc784\uc0c1\uc2dc\ud5d8 \uacb0\uacfc\ubcf4\uace0\uc11c(CSR)\uc744 \uc218\ub839\ud588\uc73c\uba70, 2025\ub144 3\uc6d4\uc5d0 \ud638\uc8fc 1b\/2a\uc0c1 \uc784\uc0c1\uc2dc\ud5d8 IND\ub97c \uc2b9\uc778 \ubc1b\uc740 \uc0c1\ud669<\/p>\n\n\n\n

\u25a0\uc548\uacfc \uad00\ub828 \uce58\ub8cc\uc81c Pipeline
\u2192\uac74\uc131 \ud669\ubc18\ubcc0\uc131\uce58\ub8cc\uc81c OLX301A : \uc784\uc0c1 1\uc0c1 \ub9c8\ubb34\ub9ac \ub2e8\uacc4\ub85c, \ubbf8\uad6d FDA\uc5d0 \uc784\uc0c1\uc2dc\ud5d8\uacc4\ud68d(IND)\ub97c \uc2b9\uc778 \ubc1b\uc544 \ub2e8\ud68c\u00b7\ub2e4\ud68c \uc6a9\ub7c9\uc0c1\uc2b9\ud22c\uc5ec\ub97c \uc644\ub8cc\ud574 \uc784\uc0c1\uc2dc\ud5d8 \uacb0\uacfc\ubcf4\uace0\uc11c\ub97c \uc218\ub839\ud560 \uc608\uc815\uc774\uba70, \uacb0\uacfc \ub370\uc774\ud130\ub97c \ubcf4\uace0 \ud5a5\ud6c4 \uae30\uc220\uc774\uc804(L\/O) \ub610\ub294 \uc790\uccb4 \uac1c\ubc1c\uc744 \uc9c4\ud589\ud560 \uc804\ub9dd
\u2192\ub9dd\ub9c9\uc0c9\uc18c\ubcc0\uc131\uc99d \uce58\ub8cc\uc81c OLX304C : \ube44\uc784\uc0c1 \uc5f0\uad6c \uc9c4\ud589 \uc911<\/p>\n\n\n\n

\u25a0\uac04 \uad00\ub828 \uce58\ub8cc\uc81c Pipeline
\u2192\ub300\uc0ac \uc774\uc0c1 \uc9c0\ubc29\uac04\uc5fc(MASH)\/\ube44\ub9cc\uce58\ub8cc\uc81c OLX702A : \ud638\uc8fc\uc5d0\uc11c \uc784\uc0c1 1\uc0c1 \uc9c4\ud589 \uc911\uc73c\ub85c, 2025\ub144 2\uc6d4 OLX702A\uc5d0 \ub300\ud55c \ub3c5\uc810\uc801 \uad8c\ub9ac\ub97c \ucd1d 9,117\uc5b5\uc6d0(\uc120\uae09\uae08, \ub9c8\uc77c\uc2a4\ud1a4 \ub4f1\uc740 \ubbf8\uacf5\uac1c)\uc5d0 \uae00\ub85c\ubc8c \uc81c\uc57d\uc0ac \uc77c\ub77c\uc774\ub9b4\ub9ac\uc5d0 \uc774\uc804\ud568. \uc784\uc0c1 1\uc0c1\uc740 2026\ub144 \uc0c1\ubc18\uae30 \uc644\ub8cc, \uc784\uc0c1 2\uc0c1\uc740 \uc77c\ub77c\uc774\ub9b4\ub9ac\uac00 \uc9c4\ud589\ud560 \uc608\uc815<\/p>\n\n\n\n

\u25a0\ub3d9\uc0ac \ub300\ud45c\ub294 \ucd5c\uadfc 2025\ub144\uc5d0 \ub450 \uac74\uc758 \uae30\uc220\uc218\ucd9c \uc57d\uc18d\uc744 \uc9c0\ud0ac \uc218 \uc788\uc744 \uac83\uc774\ub77c\uace0 \ud588\uace0, 2\uc6d4\uc5d0 \uae30\uc220\uc218\ucd9c\ud55c OLX702A 1\uac74\uc5d0 \uc774\uc5b4 \ub098\uba38\uc9c0 1\uac74\uc740 \ub2e4\uad6d\uc801 \ud68c\uc0ac\uc640 \ud53c\ubd80 \ubaa8\ubc1c \ubd84\uc57c\uc5d0\uc11c \uacf5\ub3d9 \uc5f0\uad6c\uacc4\uc57d \ud615\ud0dc\uc758 \uc131\uacfc\uac00 \ub098\uc62c \uc218 \uc788\uc744 \uac83\uc73c\ub85c \uae30\ub300 \uc911(OLX104C)<\/p>\n\n\n\n

\u25a0\uc8fc\uac00\ub294 2\uc6d4 \uc77c\ub77c\uc774\ub9b4\ub9ac\uc5d0 \uae30\uc220\uc774\uc804 \uc131\uacfc \ubc1c\ud45c \ud6c4 \uae09\ub4f1\ud55c \ub4a4 4~5\ub9cc\uc6d0 Band\uc5d0\uc11c \uc57d 4\uac1c\uc6d4\uac04 \ud6a1\ubcf4 \uc911\uc778\ub370, \ucd94\uac00 \uae30\uc220\uc218\ucd9c \ub610\ub294 \uacf5\ub3d9\uc5f0\uad6c \ub4f1\uc758 \uc131\uc0ac \uc5ec\ubd80\uc640 \uc131\uc0ac \uc2dc\uc758 \uacc4\uc57d \uaddc\ubaa8\uc5d0 \ub530\ub77c \ucd94\uac00 \uc0c1\uc2b9\uc774 \uae30\ub300\ub418\ub294 \uc790\ub9ac\uc5d0 \uc704\uce58\ud574 \uc788\uc74c<\/p>\n\n\n\n

\u25a0\ud5a5\ud6c4 \uc2e0\uc57d Pipeline\uc758 \uc784\uc0c1\uc2dc\ud5d8 \uc9c4\ucc99 \uacb0\uacfc\ub97c \uc9c0\ucf1c\ubcf4\uba70 Follow-up \ud560 \uac00\uce58\uac00 \uc788\ub2e4\uace0 \ud310\ub2e8\ud568<\/p>\n\n\n\n

\n
\"\"<\/figure>\n\n\n\n
\"\"<\/figure>\n\n\n\n
\"\"<\/figure>\n<\/figure>\n","protected":false},"excerpt":{"rendered":"

(\uc774\ubbf8\uc9c0 \ub0b4 \uae00\uc790\uac00 \uc798 \ubcf4\uc774\uc9c0 \uc54a\uc73c\uba74 \uc6f9\ube0c\ub77c\uc6b0\uc800, \ud734\ub300\ud3f0 \ud654\uba74\uc744 ‘\uac00\ub85c\ud654\uba74’\uc73c\ub85c \ubcf4\uc2dc\uac70\ub098, \uc774\ubbf8\uc9c0\ub97c \ud074\ub9ad\ud558\uba74 \ud655\ub300\ud574\uc11c \ubcf4\uc2e4 \uc218 \uc788\uc2b5\ub2c8\ub2e4.) \u2605\uc62c\ub9ad\uc2a4(226950) -\uc131\uaca9 : \uc2a4\uc719~\uc911\uae30-\ucd94\ucc9c\uac00 : 51,700\uc6d0-\ubaa9\ud45c\uac00 : 60,000\uc6d0-\uc190\uc808\uac00 : 40,000\uc6d0 -\uae30\uc5c5 \uac1c\uc694 RNA \uac04\uc12d(RNA interference; RNAi) \uae30\uc220 \uc911\uc5d0\uc11c mRNA\ub97c \ud0c0\uac9f\ud55c \uc790\uac00\uc804\ub2ec \ube44\ub300\uce6d siRNA \uae30\uc220\uacfc GalNAc-asiRNA \ud50c\ub7ab\ud3fc \uae30\uc220\uc744 \uae30\ubc18\uc73c\ub85c \ub2e4\uc591\ud55c \uc2e0\uc57d\uc744 \uac1c\ubc1c \uc911\uc784. RNA \uac04\uc12d \uae30\uc220 \ud50c\ub7ab\ud3fc \ubc0f \uc2e0\uc57d […]<\/p>\n","protected":false},"author":1,"featured_media":68526,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"acf":[],"yoast_head":"\n[05.28] \ud22c\ubfd4(1++) \ucd94\ucc9c\uc8fc : \uc62c\ud574 \uc8fc\uc694 Pipeline \uc784\uc0c1, \uadf8\ub9ac\uace0 \uae30\uc220\uc218\ucd9c \uae30\ub300 \ubaa8\uba58\ud140\uc774 \uc794\ub729 - \ud558\uc774\ubd88\uc2a4(Hi,Bulls)<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/hibulls.com\/?p=68525\" \/>\n<meta property=\"og:locale\" content=\"ko_KR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"[05.28] \ud22c\ubfd4(1++) \ucd94\ucc9c\uc8fc : \uc62c\ud574 \uc8fc\uc694 Pipeline \uc784\uc0c1, \uadf8\ub9ac\uace0 \uae30\uc220\uc218\ucd9c \uae30\ub300 \ubaa8\uba58\ud140\uc774 \uc794\ub729 - \ud558\uc774\ubd88\uc2a4(Hi,Bulls)\" \/>\n<meta property=\"og:description\" content=\"(\uc774\ubbf8\uc9c0 \ub0b4 \uae00\uc790\uac00 \uc798 \ubcf4\uc774\uc9c0 \uc54a\uc73c\uba74 \uc6f9\ube0c\ub77c\uc6b0\uc800, \ud734\ub300\ud3f0 \ud654\uba74\uc744 ‘\uac00\ub85c\ud654\uba74’\uc73c\ub85c \ubcf4\uc2dc\uac70\ub098, \uc774\ubbf8\uc9c0\ub97c \ud074\ub9ad\ud558\uba74 \ud655\ub300\ud574\uc11c \ubcf4\uc2e4 \uc218 \uc788\uc2b5\ub2c8\ub2e4.) \u2605\uc62c\ub9ad\uc2a4(226950) -\uc131\uaca9 : \uc2a4\uc719~\uc911\uae30-\ucd94\ucc9c\uac00 : 51,700\uc6d0-\ubaa9\ud45c\uac00 : 60,000\uc6d0-\uc190\uc808\uac00 : 40,000\uc6d0 -\uae30\uc5c5 \uac1c\uc694 RNA \uac04\uc12d(RNA interference; RNAi) \uae30\uc220 \uc911\uc5d0\uc11c mRNA\ub97c \ud0c0\uac9f\ud55c \uc790\uac00\uc804\ub2ec \ube44\ub300\uce6d siRNA \uae30\uc220\uacfc GalNAc-asiRNA \ud50c\ub7ab\ud3fc \uae30\uc220\uc744 \uae30\ubc18\uc73c\ub85c \ub2e4\uc591\ud55c \uc2e0\uc57d\uc744 \uac1c\ubc1c \uc911\uc784. 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